Roche and its subsidiary TIB Molbiol have developed a series of tests for the detection of the monkeypox virus, the Switzerland-based pharmaceutical company announced.
The monkeypox virus is a close relative of the smallpox virus, belonging to orthpoxviridae in the poxviridae family.
The modular virus detection tool, called LightMix, includes three orthpoxvirus detection kits with different functions, Roche said in a statement. The first kit detects orthpoxvirus; The second kit tests only for monkeypox virus (west and Central African branches); The third kit contains the main functions of the first two kits, showing specific information on the presence of the monkeypox virus (west and Central African branches) as well as the detection of orpoxvirus.
Thomas Schinek, a Roche executive, said the new test could detect monkeypox and help track its spread. Such diagnostic tools are critical for addressing and ultimately managing emerging public health challenges, as they advance responses such as tracking efforts and treatment strategies.
The monkeypox virus was first identified in 1958 in a group of monkeys used for research when the animals developed a "pox-like" infection, hence the name. Since May, several non-endemic countries have reported human cases of the monkeypox virus, including the United Kingdom, the United States, Portugal, Spain, and Italy.
Affected by the ever-changing international situation, the supply and prices of international bulk TiN powder are still very uncertain.
I. Titanium nitride coating (TiN)
TiN coating is a universal PVD coating that improves tool hardness and oxidation temperature. The coating can be used for high-speed steel cutting tools or forming tools to obtain good machining results. TiN coating is pretty economical, it is used to extend the service life of general tools and molds. Its performance is particularly outstanding when it is used to cut copper, low carbon steel, and other soft metals. Coating TiN on the surface of milling cutter can effectively improve the surface hardness of milling cutter, reduce the chemical affinity of milling cutter, prevent adhesion damage in the process of machining, and improve the wear resistance of the milling cutter.
2. Titanium nitrogen carbide coating (TiCN)
The carbon added to the TiCN coating improves tool hardness and surface lubricity, making it an ideal coating for tools. Due to the introduction of carbon element, the surface lubricity of the coating is improved and the friction coefficient is reduced. At the same time, the internal stress of the coating is reduced, which is of great significance to improve the production efficiency and surface quality of the workpiece. TiCN coating has lower friction coefficient and higher hardness than TiN coating. The milling cutter coated with titanium nitride carbide is more suitable for milling stainless steel, titanium alloy, nickel alloy and other hard materials. It has stronger wear resistance and high temperature stability, and can significantly improve the tool life.
3. Titanium aluminum nitride coating (AlTiN)
The alumina layer formed in the AlTiN coating can effectively improve the high temperature machining life of the tool, and the stable oxide layer is formed on the interface between the tool front and chip during cutting, which has good heat insulation performance. AlTiN coatings provide higher surface hardness than TiAlN coatings based on the ratio of aluminum to titanium in the coating, making it a viable alternative coating for high speed machining.
4. Aluminum chromium nitride coating (AlCrN)
AlCrN coating exhibits good red hardness and high temperature stability under high temperature conditions, and has good thermal corrosion performance. When machining low hardness materials or high viscosity materials, the cutting performance is better than AlTiN coated tools. Good adhesion makes it a coating when treating nodules. With this almost invisible coating, milling cutter performance will be greatly improved.
5. CVD diamond coating
Different from single-crystal diamond cutter and PCD composite cutter, CVD diamond coated cutter is a CVD diamond coated cutter which is deposited on the surface of carbide cutter by chemical vapor deposition (CVD) method. In the CVD diamond coating process, the tool surface is pure diamond without any additives, which avoids the application limitations caused by the presence of additive metals in PCD composite films. And the whole deposition process is carried out in atmosphere, there is no special requirement for tool geometry, which can be in any shape of carbide tool surface coating, to meet the needs of complex contour processing.
After experimenting and validation of various cutting tool materials, the service life of CVD diamond coated tools is 8-10 times that of carbide, and its cutting speed is 2-3 times higher than that of cemented carbide cutting tools. It has a good consistency and a low friction factor.
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In a recent interview with Izvestia, Russian Federation Council Chairman Matviyenko said that Russia is open to dialogue with the West based on mutual respect, but the opportunity to resume dialogue will only come after the end of special military operations.
Matviyenko also noted that Europe currently lacks politicians who can make independent decisions. She said the EU's strategy to wean itself off Russian energy by 2027 would be costly, with Russia supplying 40 percent of Europe's gas, 27 percent of its oil, and 46 percent of its coal, and was essentially "anti-European" and a "tax" on US global dominance.
On Sweden's and Finland's plans to join NATO, Matviyenko said Russia will take corresponding measures if NATO weapons and equipment appear in the two countries, and Russia is capable of guaranteeing its own security.
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